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What is a THC Tolerance Break? (Can CBD Help During a T-Break?)

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Whether you smoke weed everyday like Snoop Dogg or simply take a few tokes a day, there comes a time in most cannabis consumers’ lives where a tolerance break is in order.

If you’re a regular cannabis consumer, let’s be real. After smoking weed on the reg, day in and day out, you’ve likely experienced a bit of burnout.

We’re not going to lie, we’ve been there ourselves. This is exactly why we’re firm believers in taking a THC tolerance break from time to time.

What exactly is a THC tolerance break? And why do people take one?

What is a THC Tolerance Break?

A THC tolerance break (tolerance break or t-break for short) is just what it sounds like.

It’s the deliberate practice of taking a break from THC to clear the body and mind from the effects of the psychoactive cannabinoid.

Do regular cannabis consumers actually build up a tolerance to the effects of herb?

Research says yes.

Let’s take a deeper look.

What is THC Tolerance?

A 1995 article published in High Times, Marijuana and the Brain, Part II: The Tolerance Factor, highlighted a 1993 study that looked at chronic cannabinoid administration in rats.

Six different groups of the lab animals were given either CBD, THC, a synthetic cannabinoid, or a placebo, where changes in behavioral responses were then compared with changes of density in six various areas of the brain.

According to the article, the THC doses given to the rats were some ten times greater than what a “heavy human marijuana smoker would consume in a day.”

Keep in mind, the study was conducted in 1993…a time when weed didn’t even come close to as strong as it is today.

Regardless, the study found what many cannabis smokers already know.

According to the study’s researchers, “The result [of the study] has implications for the consequences of chronic high levels of drug use in humans, suggesting diminishing effects with greater levels of consumption.”

It was discovered that the body adapts to the ingestion of large amounts of THC by reducing the number of cannabinoid receptors available in the body.

This reduces the effects of the psychoactive cannabinoid over time.

As a heavy consumer’s body adapts to these changes in the endocannabinoid system, they won’t continue to feel the same effects of cannabis.

Basically, the more pot you smoke, the less high you get.

Welcome to the number one reason why many heavy cannabis consumers choose to take a tolerance break.

Let’s be real, though.

If you smoke weed regularly, you know that chronic cannabis consumption can put a serious dent in your drive.

Experiencing Burnout with Too Much THC

Burnout is real, especially amongst those who are heavy cannabis consumers (those who are borderline dependent).

Think you can’t become dependent on cannabis? Think again. We’re not talking being addicted to weed like one might be to heroin or cocaine. A dependency to cannabis is usually different than the extremes people imagine when it comes to drug addiction.  

We’re talking dependency, which has shown to be most common in adults that average 10 years or more of almost daily use that have made serious attempts to quit at least six times.

According to a 2007 review, individuals who’ve become dependent on cannabis may continue to smoke daily despite experiencing the following:

  • Social, psychological, and physical impairments
  • Relationship and family problems
  • Guilt associated with using cannabis
  • Financial difficulties
  • Low energy and self-esteem
  • Dissatisfaction with low productivity levels
  • Sleep and memory problems
  • Low life satisfaction

If any of these sound familiar, it could be time to take a tolerance break.

Note: a tolerance break from THC is for a person who is not addicted to cannabis but just needs a break. If you or your loved one are struggling with addiction to cannabis, consider seeking professional help as you may need more than just a tolerance break.

THC Consumption and Dopamine

Here’s something else to consider when possibly considering a THC tolerance break.

Research indicates that there is a reduction in dopamine levels where excessive cannabis use is concerned.

What is dopamine responsible for, exactly?

The neurotransmitter plays a major role in regulating behavior, mood, sleep, and cognition. It’s associated with reward and motivation, as well as creativity and decision-making.

A 2017 study found that heavy users of cannabis produced significantly lower levels of dopamine than light users or those that don’t use at all.

What exactly does this have to do with taking a tolerance break?

You know that burnout feeling that comes with smoking weed all day every day?

Dopamine plays a big role.

The neurotransmitter is something responsible for how much effort is needed to complete a task and what the rewards are.

People with higher dopamine levels are more apt to take on activities that demand energy.

Low levels of dopamine are known to cause decreased motivation, lack of interest in life, procrastination, fatigue, mood swings, inability to experience pleasure, interrupted sleep patterns, and more.

THC, Tolerance Breaks, and Your Endocannabinoid System

What are the effects of recurrent THC consumption on the endocannabinoid system itself?

Doesn’t THC work in harmony with the body’s natural endocannabinoid system to inspire homeostasis? It’s possible and as more science comes out, we will know for sure.

But too much of anything isn’t necessarily always a good thing. When it comes to homeostasis, it all depends on how much THC is consumed.

We mentioned earlier that consuming large amounts of THC reduces the number of cannabinoid receptors in the body, which reduces the effects one feels.

Research indicates that when someone consumes THC day in and day out, it produces excessive and prolonged stimulation of the CB1 receptor, which is speculated to disrupt endocannabinoid function.

It’s also been suggested that overstimulation of the CB1 receptor is something that could lead to THC-induced psychosis.

If someone is a chronic cannabis consumer, could taking a THC tolerance break actually help reset endocannabinoid function?

Could consuming less THC help those who’ve thrown their endocannabinoid system out of whack by consuming too much?


Tolerance can become so affected by chronic consumption that even taking a huge dab won’t even cause an effect in some of the heaviest smokers.

Research into the complexity of cannabis and how it works with the body is still in its infancy, however, is increasing exponentially with each passing year.

Until then we have mostly a lot of anecdotal evidence to rely on.

Ask any heavy consumer what stopping for 7-10 days does and they’re likely to tell you that taking a while off weed resets their system and restores their tolerance levels.

5 Tips to Taking a Tolerance Break

Think it’s time for a t-break?

If you’re someone who could benefit from a tolerance break for whatever reason, we’ve compiled a few tips to get you through the time it takes to reset your endocannabinoid receptors so you can resume your love affair with Mary Jane.

1. Understand it Might Not Be Easy

I think everyone who’s ever said they’re going to take a tolerance break knows about the whole mentality of “weed’s not addictive, I can quit whenever I want” mentality…but when it comes down to actually doing it, they realize it’s harder than they might’ve expected.

Here’s the thing, though. Anything you do day in and day out is going to be difficult to stop doing. This goes for being glued to your cell phone 24/7, drinking coffee every day, eating, and all the other things you do on a daily basis. Our bodies and minds crave that which is familiar.

Keep this in mind on your tolerance break. Even after a few days when that voice creeps in to remind you of how much better life is when you wake and bake…do your best not to listen. Weed will still be there in the mornings when your tolerance break is over. Just make sure you go in knowing it might not be as easy. But it can be done. And you’re likely to thank yourself when it’s over. Talk about a whole new level of appreciation.

2. Consider Cutting Down Before Quitting Cold Turkey

Heavy consumers may want to consider cutting down gradually before cutting out THC cold turkey.

Pick a date you want to start your tolerance break and begin cutting down your consumption a couple weeks beforehand.

Cutting down gives your body and endocannabinoid system time to adjust and makes actually “quitting” for a bit a far easier process.

If you’re someone who likes to smoke in the morning, start to skip out on the weed first thing. Wait until mid-day, and over the course of a couple weeks get to the point where you’re only taking a couple hits before bed.

Trust us. We speak from experience. Slowly cutting down and giving your body time to adjust is MUCH easier than quitting all at once.

3. Remove all Weed and Pot Paraphernalia from Your House and Immediate Surroundings

When it comes time to actually stop consuming cannabis altogether, it’s vital to remove all your cannabis and everything associated with it either out of the house or out of view.

The whole “out of sight, out of mind” thing is something to really keep in mind when you’re taking a tolerance break.

Consider moving everything into the garage or another room in your house. This includes any flower, concentrate, oil, papers, pipes, bongs, dab rigs, and the like. It’s pretty easy to stay tempted when you can see your favorite bong staring back at you.

Whether in your house, car, or wherever else you’re privy to stashing your stash…get rid of it.

If you can’t trust yourself not to get it out of its hiding spot, give it to a friend to hold onto for you until your tolerance break over.

4. Stay Busy/Get Creative/Engage in New Activity

If you’re a regular cannabis consumer, your first t-break can be strange. There’s suddenly such a different perspective of time. Sometimes you’ll feel this rush of energy that can make you feel like you don’t know what to do with yourself.

During your THC tolerance break, it’s important to stay busy. Take up a new hobby, organize that closet you keep putting off, engage in some arts and crafts, do whatever it is you’ve been thinking about doing but possibly put off because you were high all the time.

Not only will this keep your mind occupied, but can is also an awesome way to create new habits.

When you do start consuming again, you can bring these new habits with you (because any regular consumer knows that weed makes doing something you love just that much better).

5. Keep Focused and Committed

While taking a THC tolerance break isn’t as easy as it might sound at first, staying committed to doing it can be more rewarding than you might think.

You will be tempted to consume during the time you take a break. Do yourself a favor and don’t give into these urges.

Stay focused and understand that the discipline it takes to keep your commitment will have a significant impact on all areas of your life.

You’re not quitting cannabis for good. You’re just taking a break.

When it’s over, you’ll realize just how worth it the break really was the first time you light up.

How Long Should a Tolerance Break Last?

When it comes to taking a t-break, everyone is different.

Some might need just a few days to reset the system. Our last tolerance break was just shy of two weeks.

Chronic consumers who smoke all day, every day might want to consider taking a month off.

World renown podcaster and cannabis enthusiast, Joe Rogan and his friends do a “Sober October” every year. They take a month off weed and alcohol as a healthy reset.

You know your body better than anyone. The whole three weeks/21 days to form a habit is always a good rule of thumb to follow to get you started.

Can CBD Help with a Tolerance Break?

What about taking CBD during a THC tolerance break?

Can it help?

Maybe. We still need more research on this and CBD in general but there’s plenty of anecdotal evidence on this one.

THC and CBD react differently in the endocannabinoid system. THC binds directly to the CB1 receptor in such an adept manner that this binding affinity has been referred to as a “lock and key” system.

CBD, on the other hand, has zero binding affinity with CB1 or CB2 receptors. Instead, the non-psychoactive cannabinoid uses indirect means for regulating the endocannabinoid system to bring a state of homeostasis back to the body.

According to neuroscientist and endocannabinoid expert Dr. Ethan Russo, CBD is a “endocannabinoid modulator.” This means that CBD helps regulate the endocannabinoid system and restore overall balance to the body and brain.

That being said, CBD could have a significant impact on the endocannabinoid system during a THC tolerance break.

While more research is warranted, CBD could be beneficial when taking a tolerance break.

While limited, we do have some data which shows that CBD can be helpful for marijuana and other addictions.

Anecdotally speaking, we know that taking a few hits of a CBD preroll here and there helped us immensely during a recent tolerance break.

Incorporating CBD into your tolerance break could help with the lack of focus, anxiety, or poor sleep you might feel when taking a break from THC.

Medical marijuana users find that CBD can be helpful as an alternative for some of the symptoms they were previously using THC for primarily.

Whether it’s vaping, smoking CBD flower, or taking a tincture, CBD could be of significant benefit during your break.

At CBD School we are nerds for all the data we can get. Have you used CBD during a tolerance break from THC? Was it helpful? Please tell us about it in the comments section at the end of this article!

Final Thoughts on Taking a THC Tolerance Break

Think a tolerance break might be in order?

If you’re not feeling the same effects from THC as you used to or have discovered you’re experiencing a bit of burnout, a tolerance break might be in order.

The endocannabinoid system can get overloaded from overconsumption of THC and stop functioning in the most ideal manner.

Taking a break could reset the delicate balance of the endocannabinoid system so tolerance levels resume and you’re once again feeling elevated.

CBD could help the whole process during a t-break by encouraging overall homeostasis to a system that’s otherwise out of whack. CBD can also provide relaxation or alleviation of symptoms.

Whether your tolerance break lasts three days, a couple weeks, or a month or more, one thing’s for certain. When you return to consuming cannabis, you’ll have developed a whole new appreciation for the way it makes you feel.

Have you taken a THC tolerance break before?

We’d love to hear your story it in the comments below.

The post What is a THC Tolerance Break? (Can CBD Help During a T-Break?) appeared first on CBD School.

CBD for Athletes. The Need To Know!


Casey Willax Above: “I am just stoked to be apart of the Nanocraft team. As a pro snowboarder we abuse the heck out of our bodies day after day! It is like a precursor to my health, when I know its gonna be a long day of riding I use the products to prevent swelling and tone things down after a long hard day… The day formula is pretty bomb in coffee too”

It is no secret that athletes tend to physically abuse their bodies more than any other demographic, both positively and negatively. When it comes to training and sport specific activities, an athlete will increase human performance through endurance training, muscle loading and increasing neuromuscular communication. As a result, athletes tend to overuse their bodies, often resulting in chronic pain, inflammation and career ending injuries.

Currently, athletes who are not totally informed will take traditional pain management routes, which often consist of bed rest, NSAIDS and opioids until cleared for “return to play”. In more recent times, athletes have become smarter about how they treat their bodies and ultimately, what they put in them for performance and recovery purposes. Research and literature has recently begun to express the safety and efficacy on the use of cannabidiol (CBD) for pain and inflammation management and recovery.

It is nothing new to the industry that there is an opioid epidemic. Chronic use of over the counter medications pose a huge health risk and have shown to lead to addiction of harder pain management drugs that killed 52,404 U.S. citizens, over 33,000 (63.0%) involved an opioid in 2015 and the numbers have only grown since. There has been progress in preventing deaths of certain prescriptions, but ultimately rates of deaths involving heroin and synthetic opioids have increased nation wide, Gladden et al., 2016, Peterson et al., 2016.


Traditionally, no, but as of 2018 the world anti doping agency (WADA) and the US antI-doping agency removed CBD from the banned substance list. While the ban on THC still remains in effect, the threshold in which is considered tolerable was increased 10 fold, due to the fact that whole plant hemp derived CBD products can contain trace amounts of THC.

The only issue that athletes may currently face is that legislation regarding the usage of cannabis oil is constantly evolving, on the federal, state and local levels. This means that athletes in certain areas still may have some issues acquiring the product in their region, which still causes people to raise the question as to whether or not they should be purchasing and utilizing the product.


Athletes are now able to consume CBD products legally, but why? What will they use it for specifically?

In more recent years it has become evident that the bodies endocannabinoid system plays a significant role in modulating neuronal and immune system activity. Cannabidiol (CBD) is a phytocannabinoid found naturally in the cannabis plant. Unlike THC, CBD is not psychoactive and multiple studies have been conclusive in the fact that it can be used to treat ailments associated with inflammation and pain. Although the research is constantly evolving, the direction is pointing towards a new frontier in terms of holistic methods to treat pain and inflammation.

CB1 receptors are found throughout the central nervous system, and other tissues. CB2 receptors are more often found throughout the immune system. CBD indirect interactions with CB1 receptors has a greater effect on the central nervous system, and CBD interacting with CB2 receptors has a greater effect on reducing inflammation and ultimately act to maintain homeostasis through the adaptive and innate responses of immunity. As an athlete, often time neuromuscular communication is overused, causing central fatigue and muscle damage. CBD may act to facilitate recovery time at the cellular level.

Studies of animal models have identified that transdermal (topical CBD pain salves) applications of CBD allow for the accumulation within the skin and skeletal muscle by indirect action on cannabinoid receptors, which are identified as receptors of both the immune system and central nervous system and play a major role in cytokine release, an important step in the inflammatory process. A recent study explained that results of a chemical analysis of the spinal cord revealed that dose dependent reductions in pro-inflammatory markers were seen within the spinal cord after administering topical CBD over four consecutive days, Hammell et al., 2016.

Data would suggest that transdermal CBD and oral tinctures application have therapeutic potential for relief of pain associated with acute and chronic inflammation without evident side effects. Although more research is needed to prove this application in humans, animal models have shown strong evidence to believe that CBD may indeed provide a very potent transdermal (topical) pain relief with anti-inflammatory properties.

Taylor Knox Below: “CBD has completely changed the game in terms of sports recovery. The opioid epidemic has destroyed careers and lives… Now that I am getting older, I am a father and still performing at a high level, I need to ensure that what I am putting in my body is going to actually improve my quality of life, and it does”



Studies have shown cannabis is effective for reducing pain, including musculoskeletal pain from exercise, as well as stiff joints induced by exercise and sport, Halawa et al., 2018.

Despite the lack of conclusive amounts of evidence, due in part because of federal regulation disabling more research in the U.S, CBD does appear to relieve pain effectively for many athletes.

Inflammation can be good for athletes and help stimulate positive training adaptations. You can really look at inflammation as a good physiological response to a bad situation. Inflammation typically characterizes that the body is addressing trauma to the area, specifically muscle in athletes and facilitating growth (Hypertrophy). Too much inflammation hinders recovery and hurts performance. There are CB2 receptors in both the brain and periphery, but they are more concentrated in immune tissues. Cannabinoids interact with CB2 receptors, which seem to have an anti-inflammatory effect by reducing cytokine (cell messengers) production locally, Nagarkatti et al., 2019. In other words, CB2 receptors help tone down the response and excitability when your immune system is triggered after intense bouts of physical activity, Booz et al., 2011.

Mason Ho Below: “Now that I am getting older I am way more in tune with my body. CBD has been a game changer and when the waves are on and I don’t have it… Thats when I truly know how impactful it can be to my surfing”


Athletes traditionally consumed over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil) for decades. However, recent evidence has advocated for the dangers imposed on the Kidney’s when you consume them in excess. Long-term or frequent use of NSAIDs may also increase your risk for heart attack and stroke caused by embolism. Some athletes have found the pain relieving effect of CBD can reduce or eliminate their use of NSAIDS for exercise-related pain and no documented deaths from cannabis or cannabinoid-based products have ever been recoded.


According to the CDC, in 2017 prescription medications were involved in more than 70,000 deaths in the US. Of those deaths 67.8% were Opioid pain medications (i.e. morphine, codeine, oxycontin). A significant increase since the release of 2015 CDC statistics.

These drugs are highly effective for pain management, but have a significant risk involved in taking these drugs for any duration of time. Cannabinoids are not as effective as opioids for relieving acute, high-intensity pain, but may be effective for long-term pain management without any side and adverse affects associated with it.


Inflammation in the small and large intestines causes a lot of discomfort, and GI distress is one of the leading reasons endurance athletes drop out of races. CBD won’t solve stomach problems from dehydration and overheating, that’s a different battle. Cannabidiol (CBD) appears to be a very promising compound because of the anti-inflammatory effects. Investigators have explained the results of a study that indicated CBD is a potent compound that is able to modulate gut inflammation through poorly understood mechanisms of action between the central nervous system and the gut, Filippis et al., 2011. This may have future implication that may enable future research to confirm these findings


Currently around 25% of the American people experience sleeping issues such as insomnia. Additionally, research has shown that people with chronic insomnia are more likely to develop or have depression and vice versa.

Getting quality sleep is one of the most effective ways an athlete can achieve greater gains and is equally as important as the training itself. On an individual basis, athletes who consume CBD report improved sleep quality and duration. One potential reason for this could be CBD inhibiting the reuptake of adenosine, Rodriguez et al., 2009.

Adenosine triphosphate (ATP, Body Fuel) breaks down as your body burns substrate (Protein, Fat, Carbs) for energy and adenosine gradually accumulates in the brain. More adenosine binding to neurons inhibits the release of neurotransmitters, slowing down neuronal activity, helping you feel calmer, and inducing sleep.

By binding to same receptors adenosine would bind to, CBD may inhibit adenosine reuptake, which helps it accumulate more quickly and makes you feel tired. CBD may also have a potent anti-anxiety effect for some people, which can help them get to sleep and have more restful sleep by stabilizing cardiac rhythm during sleep.

Eli Olson Below: “Since coming onboard with Nanocraft CBD my sleeping patterns have improved. All my friends and family know how bad I struggle with insomnia. Often times I find myself going on runs at 3 AM because I can’t sleep. The night and day formulas have been a game changer when I have those long days in the dojo and surfing… Recovery has been phenomenal”


It seems as though everyday you wake up to discover some new way to ingest CBD. Whether it is soft gels, vapor pens, super-food powder, pain salves, tinctures and everything in between, there is a way for almost all demographics to get CBD into the body.

How you use it can also determine the potency and time in which the constituent actives the cannabinoids receptors. Vapor would essentially be the most immediate, due to the fact that once the cannabis diffuses through pulmonary capillaries and loads onto the red blood cells, it then  travels to the heart and up the carotid artery directly to the blood brain barrier enabling immediate and potent activation of the endocannabinoid system. However, it is still skeptical whether or not the product should be inhaled at all, due to the fact that putting anything in your lungs aside from air may have a negative impact on long-term health

Edibles have to be digested, so they may take a bit longer than vaping. CBD Topical creams may also be quicker than edibles, but often times it may take a couple applications to allow CBD to cross the dermal layers of the skin and sublingual drops/tinctures are said to be the most rapid aside from the vapor.

CBD is now available in three different forms that are derived from many extraction methods. It is available in full spectrum, broad spectrum and isolate form. Full-spectrum allows extraction of the entire cannabis plant, which typically contains up to .3% THC (legally) and contains over 100 different phytocannbinoids which create that potent “entourage” effect. Broad spectrum, similar to full-spectrum CBD (whole plant) but does not contain any THC, making it a little less potent and enables athletes that undergo routine drug tests to still reap the benefits of CBD. Isolate is the final form and is characterized as being just pure extracted CBD up to 99.9% which has been said to have therapeutic benefits, but not to the extent of full spectrum and broad spectrum formulas.


This part gets a little grey when it comes to prescribing a specific dose or giving recommendations. Currently, cannabis products are not regulated by the FDA therefore it is not very consistent when it comes to contents of the product and can be something that you really want to do your homework on before committing to a cheap product. Plus, just like any other individual human response, not one recommendation is going to produce the same results.

Most CBD companies that sell tinctures bottle them in 30ml tincture bottles and the servings are geared towards 1ml/day, making each bottle about a months worth of servings, but again, this varies person to person and I have personally turned my months worth of servings into about 2-weeks for the benefits I am looking for.


Although CBD has created a ton of buzz along with some interesting science and testimonials to back it, the biggest challenge the industry currently faces is that there is still so much to learn about the science, formulations and delivery. Although CBD is removed from the banned substance list, there is still much caution for certain athletes due to the fear that a product may contain THC, when is says it does not. At this point, the benefits out weigh the risk and if it can steer people away from harder pharmaceuticals that have proven to be dangerous, then we can all rest a bit easier knowing that we are advocating a consuming a natural, plant derived product.


New to CBD? check out the related link to the new user guide.

Cannabinoid options of application:

Transdermal (Skin)-Topical Salve: This application is typically used for acute and direct application. Such as an ankle sprain, arthritis, tendonitis, plantar fasciitis, carpal tunnel, tennis elbow, fibromyalgia and migraines. Full-spectrum salves provide a whole panel of cannabinoids for increased potency.

Edible Application

Tinctures: Tincture oils are utilized in full-spectrum form (whole plant derived) and Isolated forms (Pure CBD) that are applied directly under the tongue or mixed in water. This form is typically used for direct application to the central nervous system and the entire body for ailments like anxiety, stress, epilepsy, insomnia, depression, PTSD, autoimmune responses, ADHD, cancer, systemic inflammatory disease such as, cardiovascular disease, diabetes and metabolic syndrome. All applications are available as CBD isolate, broad spectrum and full spectrum.

Soft Gels: Full-spectrum soft gels essentially have the same application as tincture oils. The difference is that each soft gel is measured to a specific milligram to provide a consumer with a perfectly measured dose of CBD. This would be used for any ailments one might use CBD for, including all the ones listed above.

 Superfood powder: Super food green powder has a broad range of greens, phytonutrients, vitamins and of course CBD. This application is great to give some a nice, clean energy boost before a workout or just to get your day started naturally with improved focus.


1.) Booz G. W. (2011). Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free radical biology & medicine51(5), 1054-61.

2.) Gladden RM, Martinez P, Seth P. Fentanyl law enforcement submissions and increases in synthetic opioid-involved overdose deaths—27 states, 2013–2014. MMWR Morb Mortal Wkly Rep 2016;65:837–43.

3.) Guindon J, Hohmann AG. Cannabinoid CB 2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain. Br J Pharmacol2008;153(2):319–34.

4.) Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain (United Kingdom)2016;

5.) Halawa, Omar I., et al. “Role of Cannabinoids in Pain Management.” Essentials of Pain Medicine, 2018, doi:10.1016/b978-0-323-40196-8.00056-5.

6.) Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Mechoulam R, Drucker-Colín R. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Lett2006;.

7.) Nagarkatti, Prakash, et al. “Cannabinoids as Novel Anti-Inflammatory Drugs.” Future Medicinal Chemistry, vol. 1, no. 7, 2009, pp. 1333–1349., doi:10.4155/fmc.09.93.

8.) Peterson AB, Gladden RM, Delcher C, et al. Increases in fentanyl-related overdose deaths—Florida and Ohio, 2013–2015. MMWR Morb Mortal Wkly Rep 2016;65:844–9.

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